Open AccessUsefulness of Stress-Derived E/e’ Ratio in Asymptomatic Hypertensive Patients
Author(s) -
Ragab A. Mahfouz,
Mohammed Abdelhamed,
Islam Galal,
Moataz Elsanan
Publication year - 2020
Publication title -
pulse
Language(s) - English
Resource type - Journals
eISSN - 2235-8676
pISSN - 2235-8668
DOI - 10.1159/000511217
Subject(s) - medicine , asymptomatic , cardiology , coronary flow reserve , univariate analysis , stress echocardiography , subclinical infection , diastole , blood pressure , multivariate analysis , coronary artery disease
Purpose: We sought to investigate the usefulness of stress echocardiography-derived E/e’ in predicting subclinical atherosclerosis in asymptomatic hypertensive patients. Materials and Methods: 71 newly diagnosed untreated hypertensive patients (48 ± 13 years, 65% males) and 30 age- and sex-matched healthy controls were recruited. Resting and exercise echocardiography was performed to assess resting diastolic blood pressure and the diastolic stress parameters. Coronary flow reserve (CFR) was evaluated as well. Results: Based on CFR values, newly diagnosed, untreated hypertensives were stratified into hypertensives with microvascular dysfunction (MVD; 34 patients had CFR <2.0) and those without MVD (37 patients had CFR ≥2.0). Patients with MVD had a significantly higher C-reactive protein level ( p < 0.05) and lower metabolic equivalent values ( p < 0.05). With resting echocardiography, only the left atrial volume index (LAVI) was significantly increased in those with MVD compared with those without MVD and controls ( p < 0.05). With exercise echo, the E/e’ was significantly increased in MVD patients compared with those without MVD and controls ( p < 0.001). Importantly, the percentage of subjects with exercise E/e’ ≥15 was 76.5% (26 patients in the group with MVD), 4.1% (3 patients in the group without MVD), and 0% in controls. At univariate analysis, high-sensitivity C-reactive protein ( p < 0.05), LAVI ( p < 0.05), and exercise E/e’ ( p < 0.001) were independently associated with reduced CFR. On the other hand, at multivariate analysis, only exercise E/e’ was the independent predictor of reduced CFR in newly diagnosed hypertensives. Conclusion: We have demonstrated significant associations between exercise-derived raised left ventricular pressure and coronary MVD in newly diagnosed untreated hypertensive patients. Herein, we supposed that exercise-derived E/e’ could predict subclinical atherosclerosis and might be a risk parameter for newly diagnosed untreated hypertensive patients.