Open AccessCancer-Associated Retinopathy due to Clear Cell Renal Carcinoma
Author(s) -
Sushant Wagley,
Tu M. Tran,
Paul Mallory,
Michael S. Lee,
Karen R Armbrust,
Bruce Trautman,
Sandra R. Montezuma
Publication year - 2020
Publication title -
ocular oncology and pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.444
H-Index - 10
eISSN - 2296-4681
pISSN - 2296-4657
DOI - 10.1159/000511189
Subject(s) - medicine , renal cell carcinoma , visual acuity , malignancy , retinopathy , cancer , ophthalmology , blind spot , retinal detachment , carcinoma , nephrectomy , surgery , retinal , pathology , diabetes mellitus , kidney , artificial intelligence , computer science , endocrinology
An 84-year-old female presented with bilateral scotomas and progressive nyctalopia over 1 year. Best-corrected visual acuity was 20/50 in both eyes with reduced color vision. Goldmann visual field showed bilateral cecocentral scotomas and generalized constriction of the visual fields. This led to an electroretinogram showing an electronegative pattern consistent with autoimmune retinopathies. Infectious workup was negative. Anti-retinal antibodies were positive, leading to a presumed diagnosis of cancer-associated retinopathy (CAR). Imaging showed a previously unknown left renal lower pole mass, and she underwent a radical nephrectomy. Biopsy showed nuclear grade-3 clear cell renal carcinoma staged T1. The patient was treated with oral prednisone with no ocular improvement. We report on a rare case of clear cell renal carcinoma causing CAR. CAR is an important paraneoplastic syndrome to diagnose since the majority of ocular cases precede other manifestations of malignancy. Therefore, a timely diagnosis of CAR can be lifesaving or at least life-extending.