Open AccessProspective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs
Author(s) -
Ekaterina V. Lengert,
Е Е Тальникова,
Valery V. Tuchin,
Yulia I. Svenskaya
Publication year - 2020
Publication title -
skin pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 74
eISSN - 1660-5535
pISSN - 1660-5527
DOI - 10.1159/000511038
Subject(s) - stratum corneum , transdermal , antifungal , drug , pharmacology , medicine , penetration (warfare) , drug delivery , antifungal drug , dermatology , nanotechnology , materials science , pathology , operations research , engineering
Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. The present overview is focused on novel nano-based formulations served to improve antimycotic penetration through the skin. Furthermore, it summarizes various approaches towards the stimulation of drug penetration through and into the stratum corneum and hair follicles, which are considered to be promising for the future improvement of superficial antifungal therapy as providing the drug localization and prolonged storage property at the targeted area.