Open AccessLipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase
Author(s) -
David Ly,
Duo Wang,
R. Max Conway,
Michael Giblin,
Sharron Liang,
Robyn Lukeis,
Li–Anne S Lim,
Luke B. Hesson,
Svetlana Cherepanoff
Publication year - 2020
Publication title -
ocular oncology and pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.444
H-Index - 10
eISSN - 2296-4681
pISSN - 2296-4657
DOI - 10.1159/000510393
Subject(s) - hmg coa reductase , medicine , melanoma , malignancy , immunohistochemistry , reductase , cancer research , pathology , enzyme , biology , biochemistry
Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.