Open AccessAn Acidic Environment Induces <b><i>APOL1</i></b>-Associated Mitochondrial Fragmentation
Author(s) -
DengFeng Li,
James A. Snipes,
Mariana Murea,
Anthony Molina,
Jasmin Divers,
Barry I. Freedman,
Lijun Ma,
Snežana Petrović
Publication year - 2020
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000509989
Subject(s) - microbiology and biotechnology , kidney , medicine , biology
Apolipoprotein L1 gene (APOL1) G1 and G2 kidney-risk variants (KRVs) cause CKD in African Americans, inducing mitochondrial dysfunction. Modifying factors are required, because a minority of individuals with APOL1 high-risk genotypes develop nephropathy. Given that APOL1 function is pH-sensitive and the pH of the kidney interstitium is <7, we hypothesized the acidic kidney interstitium may facilitate APOL1 KRV-induced mitochondrial dysfunction.