Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3 | Zendy

Neruja Loganathan | Zendy; Emma K. McIlwraith | Zendy; Denise D. Belsham | Zendy

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Bisphenol A Induces <b><i>Agrp</i></b> Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3

Author(s) -

Neruja Loganathan,

Emma K. McIlwraith,

Denise D. Belsham

Publication year - 2020

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000509592

Subject(s) - endocrinology , medicine , gene knockdown , activating transcription factor , chemistry , mapk/erk pathway , downregulation and upregulation , hypothalamus , neuropeptide , biology , unfolded protein response , endoplasmic reticulum , signal transduction , biochemistry , receptor , apoptosis , gene

Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical and obesogen. Although limited evidence exists of the effects of BPA on hypothalamic agouti-related peptide (AgRP) levels, the mechanisms underlying these effects remain unknown. Given that AgRP is a potent orexigenic neuropeptide, determining the mechanism by which BPA increases AgRP is critical to preventing the progression to metabolic disease.

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