Open AccessMesenchymal Stem Cells: A Potential Therapeutic Strategy for Neurodegenerative Diseases
Author(s) -
Panpan Yao,
Liping Zhou,
Lujie Zhu,
Binjie Zhou,
Yu Q
Publication year - 2020
Publication title -
european neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 77
eISSN - 1421-9913
pISSN - 0014-3022
DOI - 10.1159/000509268
Subject(s) - mesenchymal stem cell , induced pluripotent stem cell , regenerative medicine , disease , stem cell , stem cell therapy , cell therapy , medicine , neuroscience , neural stem cell , biology , pathology , embryonic stem cell , microbiology and biotechnology , biochemistry , gene
Neurodegenerative disease is a kind of chronic, progressive nervous system disease characterized by neuron degeneration or apoptosis. Current treatments cannot prevent the development of the disease. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSCs). MSCs are pluripotent stem cells with capacities for self-renewal and multidirectional differentiation. MSCs may serve as a reliable source of neural cells for potential cell replacement therapy or regenerative medicine treatment. Here, we summarized the therapeutic mechanisms of MSCs and how they can contribute to the development of treatments for neurodegenerative diseases.