Open AccessIntra-Amniotic Sildenafil Treatment Promotes Lung Growth and Attenuates Vascular Remodeling in an Experimental Model of Congenital Diaphragmatic Hernia
Author(s) -
Frances C. Okolo,
GuangFeng Zhang,
Julie A. Rhodes,
George K. Gittes,
Douglas A. Potoka
Publication year - 2020
Publication title -
fetal diagnosis and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 60
eISSN - 1421-9964
pISSN - 1015-3837
DOI - 10.1159/000508986
Subject(s) - congenital diaphragmatic hernia , medicine , nitrofen , sildenafil , lung , respiratory distress , fetus , diaphragmatic hernia , andrology , endocrinology , anesthesia , pregnancy , surgery , biology , hernia , genetics
Defective lung development resulting in lung hypoplasia and an attenuated and hypermuscularized pulmonary vasculature contributes to significant postnatal mortality in congenital diaphragmatic hernia (CDH). We hypothesize that deficient embryonic pulmonary blood flow contributes to defective lung development in CDH, which may therefore be ameliorated via enhancement of embryonic pulmonary blood flow.