Open AccessGut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids
Author(s) -
Sepideh Gharaie,
Sanjeev Noel,
Hamid Rabb
Publication year - 2020
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 72
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000508984
Subject(s) - dysbiosis , microbiome , medicine , crosstalk , gut microbiome , immune system , acute kidney injury , gut flora , pathophysiology , bioinformatics , immunology , biology , physics , optics
Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O’Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.