Open AccessIs Tubular Dysfunction a Risk Factor for AKI?
Author(s) -
Alexander L. Bullen,
Joachim H. Ix
Publication year - 2020
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000508697
Subject(s) - medicine , albuminuria , acute kidney injury , renal function , risk factor , urology , nephrology , intensive care medicine , cardiology
Tubular functions are critical for homeostasis maintenance. However, tubular function markers are not typically assessed in routine clinical care. Recent research by our group has revealed that tubular dysfunction at baseline is a risk factor for subsequent acute kidney injury (AKI), independent of estimated glomerular filtration rate and albuminuria. Here, we describe the underlying hypotheses and biological insights and contrast the changes in tubule function versus injury both before and after an AKI episode.