
MicroRNA-31 Can Positively Regulate the Proliferation, Differentiation and Migration of Keratinocytes
Author(s) -
Wang Fei,
Gao Yuantao,
Yuan Yitong,
Du Ruochen,
Li Pengfei,
Liu Fang,
Tian Ye,
Wang Yali,
Zhang Ruxin,
Zhao Bichun,
Wang Chunfang
Publication year - 2020
Publication title -
biomedicine hub
Language(s) - English
Resource type - Journals
ISSN - 2296-6870
DOI - 10.1159/000508612
Subject(s) - review
In the past decades, the key roles of most microRNA in dermatosis and skin development have been explored one after another. Among them, microRNA-31 (miR-31) has a prominent role in the regulation of keratinocytes. Numerous studies show that miR-31 can positively regulate the proliferation, differentiation and cell activity of keratinocytes via regulating the NF-κB, RAS/MAPK, Notch signaling pathways, and some cytokines. At present, the interaction between miR-31 and the NF-κB signaling pathway in keratinocytes is a hot research topic. The positive feedback loop formed by miR-31 and NF-κB signaling may bring new ideas for the prevention of psoriasis. The abnormal state of keratinocytes is usually the pathological basis of many skin and immune system diseases. Therefore, strengthening the ability to regulate keratinocytes may be a breakthrough for a variety of diseases. At the same time, miR-31’s capacity to accelerate wound healing via positively regulating keratinocytes should be further investigated in the treatment of chronic ulcers and trauma.