Open AccessIntratumoral Heterogeneity in Uveal Melanoma
Author(s) -
Cristina Fonseca,
Rita Pinto Proença,
Sabrina Bergeron,
Luís Miguel Pires,
Júlia Fernandes,
Isabel M. Carreira,
Miguel N Burnier,
Rui Proença
Publication year - 2020
Publication title -
ocular oncology and pathology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.444
H-Index - 10
eISSN - 2296-4681
pISSN - 2296-4657
DOI - 10.1159/000508517
Subject(s) - medicine , melanoma , genetic heterogeneity , pathology , dermatology , radiology , gene , cancer research , chemistry , phenotype , biochemistry
Tumor biopsies in uveal melanoma (UM) serve mainly the purpose of prognostication and assessment of individual metastatic risk, but can be used for diagnosis in selected cases. The importance of precise information is paramount for selecting adequate surveillance protocols, patient counseling, and optimization of treatment strategies. However, intratumoral heterogeneity and sample representativity are major concerns and can interfere with the correct prediction of the patient's prognosis. We report a series of cases of UM with distinct morphologically identifiable areas, highlighting the differences in clinical behavior, as well as histopathological and genetic features.