Open AccessA Porthole over AKI: Cell Dynamics in Damage and Repair
Author(s) -
Luca Bordoni,
Donato Sardella,
Ina Maria Schießl
Publication year - 2020
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 72
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000508504
Subject(s) - medicine , acute kidney injury , fibrosis , kidney disease , crosstalk , cell , inflammation , cell damage , cell injury , pathology , molecular cell biology , bioinformatics , microbiology and biotechnology , apoptosis , biology , physics , optics , genetics , biochemistry
Acute kidney injury (AKI) is associated with an increased risk of CKD. Injury-induced multifaceted renal cell-to-cell crosstalk can either lead to successful self-repair or chronic fibrosis and inflammation. In this mini-review, we will discuss critical renal cell types acting as victims or executioners in AKI pathology and introduce intravital imaging as a powerful technique to further dissect these cell-to-cell interactions.