A Porthole over AKI: Cell Dynamics in Damage and Repair | Zendy

Luca Bordoni | Zendy; Donato Sardella | Zendy; Ina Maria Schießl | Zendy

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A Porthole over AKI: Cell Dynamics in Damage and Repair

Author(s) -

Luca Bordoni,

Donato Sardella,

Ina Maria Schießl

Publication year - 2020

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000508504

Subject(s) - medicine , acute kidney injury , fibrosis , kidney disease , crosstalk , cell , inflammation , cell damage , cell injury , pathology , molecular cell biology , bioinformatics , microbiology and biotechnology , apoptosis , biology , physics , optics , genetics , biochemistry

Acute kidney injury (AKI) is associated with an increased risk of CKD. Injury-induced multifaceted renal cell-to-cell crosstalk can either lead to successful self-repair or chronic fibrosis and inflammation. In this mini-review, we will discuss critical renal cell types acting as victims or executioners in AKI pathology and introduce intravital imaging as a powerful technique to further dissect these cell-to-cell interactions.

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