Open AccessEffect of Thyroid Hormones on Adipose Tissue Flexibility
Author(s) -
Lisa Volke,
Kerstin Krause
Publication year - 2020
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000508483
Subject(s) - adipose tissue , white adipose tissue , browning , brown adipose tissue , endocrinology , medicine , hormone , thyroid hormones , thyroid , biology , horticulture
The recruitment and activation of energy-consuming brown adipocytes is currently considered as potential therapeutic approach to combat obesity. Thyroid hormones (TH) significantly contribute to full thermogenic capacity of brown adipocytes. A number of recent studies suggest that TH also induce the recruitment of brown adipocytes in white adipose depots, a process known as browning. In this review, we will summarize underlying mechanisms by which TH mediate brown adipose tissue activity and white adipose tissue browning. Furthermore, we will discuss the relevance of TH-induced white adipose tissue browning for thermoregulation.