Open AccessAmyloid Beta Peptide Is an Endogenous Negative Allosteric Modulator of Leptin Receptor
Author(s) -
Erika Cecon,
Tori Lhomme,
Tangui Maurice,
Marine Luka,
Min Min Chen,
Alcino J. Silva,
Joris Wauman,
Lennart Zabeau,
Jan Tavernier,
Vincent Prévot,
Julie Dam,
Ralf Jockers
Publication year - 2020
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000508105
Subject(s) - allosteric regulation , leptin receptor , leptin , allosteric modulator , receptor , endocrinology , medicine , function (biology) , biology , microbiology and biotechnology , chemistry , biochemistry , obesity
Metabolic dysfunction is now recognized as a pivotal component of Alzheimer's disease (AD), the most common dementia worldwide. However, the precise molecular mechanisms linking metabolic dysfunction to AD remain elusive.