Open AccessOutcome of Newborn Screening for Congenital Adrenal Hyperplasia at Two Time Points
Author(s) -
Nazaneen Eshragh,
Luong Van Doan,
Kara J. Connelly,
Sara Denniston,
Sharon Willis,
Stephen LaFranchi
Publication year - 2020
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000508075
Subject(s) - congenital adrenal hyperplasia , newborn screening , medicine , 21 hydroxylase , pediatrics , cutoff , screening test , obstetrics , physics , quantum mechanics
Screening newborns for congenital adrenal hyperplasia (CAH) is problematic owing to the dynamic changes in serum 17-hydroxyprogesterone (17-OHP) levels following birth. Our study objectives were to determine the accuracy of screening, severity of CAH, and biochemical and clinical outcomes of cases detected by our program which collects specimens at 2 time periods following birth.