Profiling of the Peripheral Blood Mononuclear Cell Proteome in Schizophrenia and Mood Disorders for the Discovery of Discriminatory Biomarkers: A Proof-of-Concept Study | Zendy

Violette Coppens | Zendy; Oskar De Wachter | Zendy; Jobbe Goossens | Zendy; Jolien Hendrix | Zendy; Stuart Maudsley | Zendy; Asfar S. Azmi | Zendy; Jaana van Gastel | Zendy; Alysia Van Saet | Zendy; Tina Lauwers | Zendy; Manuel Morrens | Zendy

Open Access

Profiling of the Peripheral Blood Mononuclear Cell Proteome in Schizophrenia and Mood Disorders for the Discovery of Discriminatory Biomarkers: A Proof-of-Concept Study

Author(s) -

Violette Coppens,

Oskar De Wachter,

Jobbe Goossens,

Jolien Hendrix,

Stuart Maudsley,

Asfar S. Azmi,

Jaana van Gastel,

Alysia Van Saet,

Tina Lauwers,

Manuel Morrens

Publication year - 2020

Publication title -

neuropsychobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.71

H-Index - 83

eISSN - 1423-0224

pISSN - 0302-282X

DOI - 10.1159/000507631

Subject(s) - bipolar disorder , context (archaeology) , biomarker , major depressive disorder , schizophrenia (object oriented programming) , medicine , psychology , mood , psychiatry , biology , genetics , paleontology

Current diagnoses in psychiatry are solely based on the evaluation of clinical presentation by the treating psychiatrist. This results in a high percentage of misdiagnosis and consequential inefficient treatment; especially regarding major depressive disorder (MDD), depression in the context of bipolar disorder (BD-D), bipolar disorder with manic symptoms (BD-M), and psychosis in the context of schizophrenia (SZ). Objective biomarkers allowing for accurate discriminatory diagnostics are therefore urgently needed.

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