Open AccessPathophysiologic Role of Molecules Determining Arteriovenous Differentiation in Adult Life
Author(s) -
Fang Liu,
Zhong Yao,
Ping Lü,
Qibin Jiao,
Qin Liu,
Hailing Wu,
Yun You,
Susumu Minamisawa
Publication year - 2020
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000507627
Subject(s) - pathophysiology , biology , blood vessel , pathology , vascular disease , medicine , endocrinology
The structural differences between arteries and veins are genetically predetermined. Vascular identity markers, the molecular markers specific to veins and arteries, determine the differential development of vessels during embryogenesis and their expression persists in adult vessels. It is revealed that they can be reactivated under various pathophysiologic conditions even after vessel differentiation. Thus, once considered as quiescent in adults, vascular identity markers may actually play significant roles in vascular remodeling. Manipulation of vascular identity and the underlying molecular mechanisms might be a novel strategy to improve vascular remodeling for clinical application.