Open AccessMutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas
Author(s) -
Nathália C. Campanella,
Eduardo Caetano Albino da Silva,
Gustavo Dix,
Fabiana de Lima Vazquez,
Flávia Escremim de Paula,
Gustavo Nóriz Berardinelli,
Marcelo Luiz Balancin,
Roger Chammas,
Rossana Verónica Mendoza López,
Henrique C. S. Silveira,
Vera Luíza Capelozzi,
Rui Manuel Reis
Publication year - 2020
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000507373
Subject(s) - neuroblastoma ras viral oncogene homolog , kras , bap1 , pdgfra , mesothelioma , cancer research , amplicon , gnaq , ros1 , cdkn2a , biology , gene , mutation , medicine , cancer , pathology , adenocarcinoma , gist , genetics , stromal cell , polymerase chain reaction
Malignant pleural mesothelioma (MPM) is a highly lethal disease comprising a heterogeneous group of tumors with challenging to predict biological behavior. The diagnosis is complex, and the histologic classification includes 2 major subtypes of MPM: epithelioid (∼60% of cases) and sarcomatous (∼20%). Its identification depends upon pathological investigation supported by clinical and radiological evidence and more recently ancillary molecular testing. Treatment options are currently limited, with no known targeted therapies available.