Open AccessTest Gene-Environment Interactions for Multiple Traits in Sequencing Association Studies
Author(s) -
Jianjun Zhang,
Qiuying Sha,
Hao Han,
Shuanglin Zhang,
Xiaoyi Gao,
Xuexia Wang
Publication year - 2019
Publication title -
human heredity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.423
H-Index - 62
eISSN - 1423-0062
pISSN - 0001-5652
DOI - 10.1159/000506008
Subject(s) - type i and type ii errors , genetics , biology , genetic association , gene , mathematics , statistics , genotype , single nucleotide polymorphism
The risk of many complex diseases is determined by an interplay of genetic and environmental factors. The examination of gene-environment interactions (G×Es) for multiple traits can yield valuable insights about the etiology of the disease and increase power in detecting disease-associated genes. However, the methods for testing G×Es for multiple traits are very limited.