Open AccessPlatelet Dysfunction and Its Role in the Pathogenesis of Psoriasis
Author(s) -
Zhijia Fan,
Li Wang,
Hanqiang Jiang,
Yong Lin,
Zhicheng Wang
Publication year - 2020
Publication title -
dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.224
H-Index - 92
eISSN - 1421-9832
pISSN - 1018-8665
DOI - 10.1159/000505536
Subject(s) - psoriasis , pathogenesis , medicine , platelet , hemostasis , immunology , immune system , platelet activation , thrombosis , inflammation , disease
Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis and thrombosis, and platelet dysfunction is deeply involved in the pathogenesis of psoriasis. Summary: The aim of this study is to perform a review that expounds abnormal platelet function in psoriasis and explains the important role of platelets in the pathogenic mechanism of psoriasis in order to provide new targets for comprehensive medical treatment.