Open AccessIncreased Expressions and Roles of CC Chemokine Ligand 21 and CC Chemokine Ligand 25 in Chronic Rhinosinusitis with Nasal Polyps
Author(s) -
Mengzhi Liu,
Shiming Chen,
Yu Xu,
Yonggang Kong,
Yuxiao Deng,
Fen Li,
Zezhang Tao
Publication year - 2019
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000504476
Subject(s) - ccl21 , ccl25 , chemokine , cxcl2 , immunohistochemistry , macrophage , immunology , cd163 , cc chemokine receptors , pathology , medicine , inflammation , chemokine receptor , chemistry , in vitro , biochemistry
Chronic rhinosinusitis (CRS) is a local inflammation of the nasal mucosa and sinus that persists for >12 weeks. As CC chemokine ligand (CCL) 19 expression is known to be elevated in CRS, and CCL 19, CCL21, and CCL25 share the same atypical chemokine receptor 4, so we focused on CCL21 and CCL25.