Open AccessNeurodegenerative Patterns of Cognitive Clusters of Early-Onset Alzheimer’s Disease Subjects: Evidence for Disease Heterogeneity
Author(s) -
Meredith Phillips,
Eddie Stage,
Kathleen A. Lane,
Sujuan Gao,
Shan L. Risacher,
Naira Goukasian,
Andrew J. Saykin,
María C. Carrillo,
Bradford C. Dickerson,
Gil D. Rabinovici,
Liana G. Apostolova,
Alzheimer’s Disease Neuroimaging Initiative
Publication year - 2019
Publication title -
dementia and geriatric cognitive disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.026
H-Index - 110
eISSN - 1421-9824
pISSN - 1420-8008
DOI - 10.1159/000504341
Subject(s) - psychology , statistical parametric mapping , atrophy , pittsburgh compound b , posterior cingulate , cognition , alzheimer's disease , neuroscience , audiology , medicine , cognitive impairment , magnetic resonance imaging , disease , radiology
Alzheimer's disease (AD) with onset before 65 (early-onset AD [EOAD]) occurs in approximately 6% of cases and can affect nonmemory domains. Here, we analyze patterns of impairment in amnestic EOAD individuals using data-driven statistical analyses.