Open AccessAdvancements to the Axolotl Model for Regeneration and Aging
Author(s) -
Warren Antonio Vieira,
Kaylee M. Wells,
Catherine McCusker
Publication year - 2019
Publication title -
gerontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.397
H-Index - 94
eISSN - 1423-0003
pISSN - 0304-324X
DOI - 10.1159/000504294
Subject(s) - axolotl , regeneration (biology) , biology , regenerative medicine , model organism , organism , neuroscience , stem cell , microbiology and biotechnology , genetics , gene
Loss of regenerative capacity is a normal part of aging. However, some organisms, such as the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover, the development of age-related diseases is rare in this organism. In this review, we will explore how axolotls are used as a model system to study regenerative processes, the exciting new technological advancements now available for this model, and how we can apply the lessons we learn from studying regeneration in the axolotl to understand, and potentially treat, age-related decline in humans.