Open AccessExpression and Function of a Disintegrin and Metalloproteinases in Cancer-Associated Fibroblasts of Colorectal Cancer
Author(s) -
Satsuki Mochizuki,
Tadakazu Ao,
Takumi Sugiura,
Keisuke Yonemura,
Takehiro Shiraishi,
Yoshiki Kajiwara,
Koichi Okamoto,
Eiji Shinto,
Yasunori Okada,
Hideki Ueno
Publication year - 2019
Publication title -
digestion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.882
H-Index - 75
eISSN - 1421-9867
pISSN - 0012-2823
DOI - 10.1159/000504087
Subject(s) - stromal cell , cancer , tumor microenvironment , cancer research , cancer associated fibroblasts , extracellular matrix , biology , colorectal cancer , cancer cell , stroma , pathology , matrix metalloproteinase , tumor progression , medicine , immunology , microbiology and biotechnology , immunohistochemistry , biochemistry , genetics
Cancer tissues consist of cancer cells and stroma, the latter of which dictates cancer tissue microenvironment. We recently reported that the desmoplastic reaction (DR) pattern at the invasive front in colorectal cancer (CRC) is a promising prognostic indicator. However, the molecular mechanisms of DR formation and contribution to patients' prognosis remain unclear.