Open AccessTransient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation
Author(s) -
Hiroshi Mihara,
Ammar Boudaka,
Makoto Tominaga,
Toshiro Sugiyama
Publication year - 2019
Publication title -
digestion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.882
H-Index - 75
eISSN - 1421-9867
pISSN - 0012-2823
DOI - 10.1159/000504021
Subject(s) - transient receptor potential channel , adenosine triphosphate , adenosine , exocytosis , trpv4 , purinergic signalling , pharmacology , transporter , microbiology and biotechnology , purinergic receptor , inflammation , chemistry , biochemistry , biology , receptor , adenosine receptor , secretion , immunology , gene , agonist
Transient receptor potential vanilloid 4 (TRPV4) is activated by stretch (mechanical), warm temperature, some epoxyeicosatrienoic acids, and lipopolysaccharide. TRPV4 is expressed throughout the gastrointestinal epithelia and its activation induces adenosine triphosphate (ATP) exocytosis that is involved in visceral hypersensitivity. As an ATP transporter, vesicular nucleotide transporter (VNUT) mediates ATP storage in secretory vesicles and ATP release via exocytosis upon stimulation.