miR-34a Enhances the Susceptibility of Gastric Cancer to Platycodin D by Targeting Survivin | Zendy

Yao Peng | Zendy; Jingying Fan | Zendy; Jian Xiong | Zendy; Yu Lou | Zendy; Ying Zhu | Zendy

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miR-34a Enhances the Susceptibility of Gastric Cancer to Platycodin D by Targeting Survivin

Author(s) -

Yao Peng,

Jingying Fan,

Jian Xiong,

Yu Lou,

Ying Zhu

Publication year - 2019

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000502913

Subject(s) - survivin , apoptosis , annexin , chemistry , mtt assay , cancer research , microbiology and biotechnology , cell growth , in vivo , flow cytometry , viability assay , biology , biochemistry

Platycodin D (PD), a triterpenoid saponin isolated from Platycodon grandiflorum, has a well-known anti-tumor effect in multiple human cancers, including gastric cancer (GC). miR-34a plays an important role in the progression of GC. However, the relationship between miR-34a and the susceptibility of GC cells to PD is still unclear. The aim of our research was to investigate the functions of miR-34a in mediating the susceptibility of GC to PD.

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