Open AccessmiR-34a Enhances the Susceptibility of Gastric Cancer to Platycodin D by Targeting Survivin
Author(s) -
Yuling Peng,
Jingying Fan,
Jian Xiong,
Yiting Lou,
Ying Zhu
Publication year - 2019
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000502913
Subject(s) - survivin , cancer , cancer research , medicine , chemistry
Platycodin D (PD), a triterpenoid saponin isolated from Platycodon grandiflorum, has a well-known anti-tumor effect in multiple human cancers, including gastric cancer (GC). miR-34a plays an important role in the progression of GC. However, the relationship between miR-34a and the susceptibility of GC cells to PD is still unclear. The aim of our research was to investigate the functions of miR-34a in mediating the susceptibility of GC to PD.