Open AccessPerivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo
Author(s) -
Sophie N. Saxton,
Sarah Withers,
Jakob Nyvad,
Aleksandra Mazur,
Vladimir V. Matchkov,
Anthony M. Heagerty,
Christian Aalkjær
Publication year - 2019
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000502689
Subject(s) - endocrinology , medicine , mesenteric arteries , adipocyte , adipose tissue , in vivo , vasodilation , stimulation , chemistry , biology , artery , microbiology and biotechnology
Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries in vitro, however there are no studies of PVAT effects on vascular tone in vivo. In vitro adipocyte β3-adrenoceptors play a role in PVAT function via secretion of the vasodilator adiponectin.