Open AccessImpact, Screening, and Therapy of HLA Antibodies in Patients before and after Lung Transplantation
Author(s) -
Andrea Dick,
Andreas Humpe,
Teresa Kauke
Publication year - 2019
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000502124
Subject(s) - medicine , transplantation , lung transplantation , human leukocyte antigen , tissue typing , desensitization (medicine) , histocompatibility testing , histocompatibility , intensive care medicine , immunology , surgery , antigen , receptor
Since almost 30 years, lung transplantation is a considerable therapeutic option in patients suffering from end-stage lung disease. Up to now, the impact of donor-specific antibodies directed against donor HLA (human leukocyte antigen) before and after transplantation is still a matter of debate. As histocompatibility testing is not required for each patient according to the current national guidelines and Eurotransplant recommendations for lung transplantation, each transplantation unit has to establish a local protocol together with the tissue typing laboratory how to implement an immunological risk assessment strategy for their patients while enabling access to transplantation. Desensitization regimens might help in case of highly alloimmunized patients waiting for urgent transplantation.