Open AccessFour-Week Omega-3 Supplementation in Carriers of the Prosteatotic <b><i>PNPLA3</i></b> p.I148M Genetic Variant: An Open-Label Study
Author(s) -
Clara-Sophie Kuttner,
Rosellina Margherita Mancina,
Gudrun Wagenpfeil,
Frank Lammert,
Caroline S. Stokes
Publication year - 2019
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000502008
Subject(s) - medicine , steatosis , eicosapentaenoic acid , endocrinology , docosahexaenoic acid , transient elastography , fatty liver , fatty acid , nonalcoholic fatty liver disease , biology , cirrhosis , biochemistry , polyunsaturated fatty acid , disease , liver fibrosis
The PNPLA3 loss-of-function variant p.I148M is a strong genetic determinant of nonalcoholic fatty liver disease. The PNPLA3 protein functions as an intracellular lipase in the liver, with a greater activity on unsaturated fatty acids. This study aimed to determine whether short-term supplementation with omega-3 fatty acids impacts hepatic steatosis differently in PNPLA3 p.148I wild-type individuals as compared to homozygous carriers of the PNPLA3 p.148M variant.