Open AccessUpregulation of Mitochondrial Transcription Factor A Promotes the Repairment of Renal Tubular Epithelial Cells in Sepsis by Inhibiting Reactive Oxygen Species-Mediated Toll-Like Receptor 4/p38MAPK Signaling
Author(s) -
Xingui Dai,
Tao Li,
Weibo Huang,
Zhenhua Zeng,
Qiong Li,
Yang Yang,
Ze-Peng Duan,
Yujing Wang,
Yuhang Ai
Publication year - 2019
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000501789
Subject(s) - tfam , downregulation and upregulation , microbiology and biotechnology , biology , mitochondrion , gene , biochemistry , mitochondrial biogenesis
Mitochondrial transcription factor A (TFAM) plays multiple pathophysiologic roles in mitochondrial DNA (mtDNA) maintenance. However, the role of TFAM in sepsis-induced acute kidney injury (AKI) remains largely unknown.