Open AccessNeuroinflammation and B-Cell Phenotypes in Cervical and Lumbosacral Regions of the Spinal Cord in Experimental Autoimmune Encephalomyelitis in the Absence of Pertussis Toxin
Author(s) -
Evangel Kummari,
James M. Nichols,
EunJu Yang,
Barbara L. F. Kaplan
Publication year - 2019
Publication title -
neuroimmunomodulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.635
H-Index - 65
eISSN - 1423-0216
pISSN - 1021-7401
DOI - 10.1159/000501765
Subject(s) - experimental autoimmune encephalomyelitis , myelin oligodendrocyte glycoprotein , immunology , neuroinflammation , medicine , pertussis toxin , encephalomyelitis , multiple sclerosis , immune system , receptor , inflammation , g protein
The active experimental autoimmune encephalomyelitis (EAE) model is often initiated using myelin oligodendrocyte glycoprotein (MOG) immunization followed by pertussis toxin (PTX) to study multiple sclerosis. However, PTX inactivates G protein-coupled receptors, and with increasing knowledge of the role that various G protein-coupled receptors play in immune homeostasis, it is valuable to establish neuroimmune endpoints for active EAE without PTX.