Open AccessValidation of Microbiological Testing of Cellular Medicinal Products Containing Antibiotics
Author(s) -
Ramin Lotfi,
Markus Rojewski,
Philip H. Zeplin,
W. Funk,
Oliver Pullig,
Ulrich Nöth,
Hubert Schrezenmeier
Publication year - 2019
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000501284
Subject(s) - antibiotics , clostridium sporogenes , microbiology and biotechnology , staphylococcus aureus , biology , bacteria , clostridium , genetics
The risk of microbial contamination of cellular products can be reduced when cultured in the presence of antibiotics. This however, may impact the sensitivity of microbiological tests. Given that the addition of antibiotics to cell/tissue products does not guarantee sterility but may just reduce the proliferation rate of microorganisms, microbiological testing of medicinal products remains obligatory. Thus, an appropriate method to test for microbial contamination of antibiotic-containing products has to be validated.