Open AccessEarly-Pregnancy Circulating Antioxidant Capacity and Hemodynamic Adaptation in Recurrent Placental Syndrome: An Exploratory Study
Author(s) -
C. SeverensRijvers,
Salwan AlNasiry,
Annemiek Vincken,
Guido R.M.M. Haenen,
Björn Winkens,
Chahinda GhosseinDoha,
Marc E. Spaanderman,
Louis Peeters
Publication year - 2019
Publication title -
gynecologic and obstetric investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 63
eISSN - 1423-002X
pISSN - 0378-7346
DOI - 10.1159/000501254
Subject(s) - pregnancy , medicine , preeclampsia , hemodynamics , fetus , endocrinology , hellp syndrome , gestation , biology , genetics
Placental syndromes (PS) refer to pregnancy complications that include gestational hypertension, (pre)eclampsia, HELLP syndrome, and/or placental insufficiency-induced fetal growth restriction. These disorders are characterized by increased oxidative stress. This study aims to test the hypothesis that the abnormal hemodynamic adaptation to pregnancy, typical for early PS pregnancy, is accompanied by abnormal maternal levels of antioxidants relative to those in normal pregnancy.