Open AccessAssociation between Body Weight Gain from 20 Years of Age and Diabetic Nephropathy in Japanese Patients with Type 2 Diabetes
Author(s) -
Okada Hiroshi,
Tanaka Muhei,
Hasegawa Goji,
Nakajima Hanako,
Kadono Mayuko,
Miyoshi Tomoki,
Okada Yuki,
Nakano Koji,
Yamane Tetsuro,
Fukui Michiaki
Publication year - 2019
Publication title -
kidney and blood pressure research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.806
H-Index - 51
eISSN - 1423-0143
pISSN - 1420-4096
DOI - 10.1159/000500722
Subject(s) - research article
Background/Aims: It has been reported that the body mass index shows a U-shaped association with death from cardiovascular disease (CVD) in the Asian population. The relationship between body weight (BW) gain from early adulthood and diabetic nephropathy remains to be elucidated in Japanese patients with type 2 diabetes. Our aim was to investigate the association between BW gain from early adulthood and diabetic nephropathy in Japanese patients with type 2 diabetes. Methods: We assessed the BW of 471 consecutive patients with type 2 diabetes and calculated the change in BW from the age of 20 years to the lifetime maximum (ΔBWmax-20y). We then evaluated the relationship of ΔBWmax-20y with the degree of urinary albumin excretion (UAE), which is a useful marker for CVD. Results: ΔBWmax-20y negatively correlated with the logarithm of UAE ( r = –0.160, p = 0.002). Multiple regression analysis demonstrated that ΔBWmax-20y was independently correlated with the logarithm of UAE (β = –0.112, p = 0.034). Conclusions: BW gain from the age of 20 years is correlated with diabetic nephropathy in Japanese patients with type 2 diabetes.