Effects and Mechanisms of Vitamin C Post-Conditioning on Platelet Activation after Hypoxia/Reoxygenation | Zendy

Demin Liu | Zendy; Dongguo Pei | Zendy; Haijuan Hu | Zendy; Guoqiang Gu | Zendy; Wei Cui | Zendy

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Effects and Mechanisms of Vitamin C Post-Conditioning on Platelet Activation after Hypoxia/Reoxygenation

Author(s) -

Demin Liu,

Dongguo Pei,

Haijuan Hu,

Guoqiang Gu,

Wei Cui

Publication year - 2019

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000500492

Subject(s) - chemistry , platelet , platelet activation , reactive oxygen species , cytochrome c , apoptosis , arachidonic acid , pharmacology , biochemistry , immunology , medicine , enzyme

Platelet activation occurs upon ischemia/reperfusion and is related to the generation of reactive oxygen species (ROS) during this process. Vitamin C (VC) is a powerful antioxidant. VC scavenges ROS, reduces platelet activation, and attenuates reperfusion injury. However, the effects of VC on platelets undergoing hypoxia/reoxygenation (H/R) remain unclear.

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