Open AccessEffects and Mechanisms of Vitamin C Post-Conditioning on Platelet Activation after Hypoxia/Reoxygenation
Author(s) -
Demin Liu,
Dongguo Pei,
Hongwei Hu,
Guoqiang Gu,
Wei Cui
Publication year - 2019
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000500492
Subject(s) - chemistry , platelet , platelet activation , reactive oxygen species , cytochrome c , apoptosis , arachidonic acid , pharmacology , biochemistry , immunology , medicine , enzyme
Platelet activation occurs upon ischemia/reperfusion and is related to the generation of reactive oxygen species (ROS) during this process. Vitamin C (VC) is a powerful antioxidant. VC scavenges ROS, reduces platelet activation, and attenuates reperfusion injury. However, the effects of VC on platelets undergoing hypoxia/reoxygenation (H/R) remain unclear.