Plasma Beta-Glucuronidase Activity: A Novel Tool to Distinguish Type 1 from Type 2 Amiodarone-Induced Thyrotoxicosis? | Zendy

Georgios Κ. Markantes | Zendy; Marina Michalaki | Zendy; George A. Vagenakis | Zendy; Fotini N. Lamari | Zendy; Efthymia Pitsi | Zendy; Μαρία Ηλιοπούλου | Zendy; Nicholas G. Beratis | Zendy; Kostas B. Markou | Zendy

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Plasma Beta-Glucuronidase Activity: A Novel Tool to Distinguish Type 1 from Type 2 Amiodarone-Induced Thyrotoxicosis?

Author(s) -

Georgios Κ. Markantes,

Marina Michalaki,

George A. Vagenakis,

Fotini N. Lamari,

Efthymia Pitsi,

Μαρία Ηλιοπούλου,

Nicholas G. Beratis,

Kostas B. Markou

Publication year - 2019

Publication title -

european thyroid journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.23

H-Index - 10

eISSN - 2235-0802

pISSN - 2235-0640

DOI - 10.1159/000500355

Subject(s) - medicine , euthyroid , endocrinology , subacute thyroiditis , goiter , thyroid , thyroiditis , amiodarone , thyroid function , gastroenterology , atrial fibrillation

Amiodarone-induced thyrotoxicosis (AIT) is a common and deleterious side effect of amiodarone use. There are two types of AIT, characterized by distinct pathogenic mechanisms and, hence, different treatments. Discriminating between type 1 (AIT1) and type 2 (AIT2) AIT is often very challenging. Beta-glucuronidase (β-G) is a lysosomal enzyme released into the extracellular fluid during inflammation.

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