Open AccessPlasma Beta-Glucuronidase Activity: A Novel Tool to Distinguish Type 1 from Type 2 Amiodarone-Induced Thyrotoxicosis?
Author(s) -
Georgios Κ. Markantes,
Marina Michalaki,
George A. Vagenakis,
Fotini N. Lamari,
Efthymia Pitsi,
Μαρία Ηλιοπούλου,
Nicholas G. Beratis,
Kostas B. Markou
Publication year - 2019
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.23
H-Index - 10
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000500355
Subject(s) - medicine , euthyroid , endocrinology , subacute thyroiditis , goiter , thyroid , thyroiditis , amiodarone , thyroid function , gastroenterology , atrial fibrillation
Amiodarone-induced thyrotoxicosis (AIT) is a common and deleterious side effect of amiodarone use. There are two types of AIT, characterized by distinct pathogenic mechanisms and, hence, different treatments. Discriminating between type 1 (AIT1) and type 2 (AIT2) AIT is often very challenging. Beta-glucuronidase (β-G) is a lysosomal enzyme released into the extracellular fluid during inflammation.