Open AccessA Case of Unilateral Dermopathy Possibly Related to Graves’ Disease
Author(s) -
Cosimo Rodia,
Francesca Menconi,
Laura Mazoni,
Liborio Torregrossa,
Fulvio Basolo,
Paolo Vitti,
Claudio Marcocci,
Michele Marinò
Publication year - 2019
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.23
H-Index - 10
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000500297
Subject(s) - medicine , graves' disease , disease , dermatology , pathology
The pathogenesis of the extrathyroidal manifestations of Graves' disease (GD) is not fully clarified. According to the most common hypothesis, they would reflect an autoimmune reaction against antigens constitutively expressed by the thyroid and by the extrathyroidal affected tissues. According to another hypothesis, the so-called Kriss' hypothesis, soluble autoantigens released from the thyroid would reach the affected tissues, where they would become the target of the immune system. In this regard, a shift in gravity during sleep may favour antigen deposition.