Open AccessHepatocellular Carcinoma of Fibrolamellar Type in an Adolescent: Case Report and Literature Review
Author(s) -
Javier Santiago-Reynoso,
Karina Senyase Zamaripa-Martínez,
Juan Manuel Dorantes-Loya,
Guillermo J Gaytán-Fernández,
Evelia Apolinar-Jiménez,
Francisco José Paz-Gómez,
Felipe Farias-Serratos,
María Maldonado-Vega
Publication year - 2019
Publication title -
gastrointestinal tumors
Language(s) - English
Resource type - Journals
eISSN - 2296-3766
pISSN - 2296-3774
DOI - 10.1159/000499581
Subject(s) - medicine , hepatocellular carcinoma , ascites , liver transplantation , gastroenterology , respiratory failure , transplantation
We present a female patient, 13 years old, with diagnosis of hepatocellular carcinoma of fibrolamellar type, which was rapidly evolving. The fibrolamellar hepatocellular carcinoma invaded more than 80% of the hepatic parenchyma without surgical possibility or liver transplantation. Measures applied corresponded to chemotherapy of 1 cycle of cisplatin 40 mg/s/5 days + vincristine 1.5 mg/m 2 /day, 5-fluorouracil, doxorubicin, and dexrazoxane. The case presented aggressive evolution of hepatocellular carcinoma, which led to acute liver failure, with hyperammonemia, sepsis, pulmonary focus plus septic shock, grade III-IV encephalopathy, portal hypertension, and ascites with intra-abdominal hypertension. Death occurred due to multiple organ failure, which involved respiratory failure type KDIGO 1 and 2, acute liver failure, severe pneumonia, pericardial effusion, AKIN 2 acute kidney injury, carcinoma, and pulmonary metastasis. This type of ailment is infrequent in children and adolescents, and the first symptoms are crucial to achieve treatment possibilities.