Open AccessHyperviscous Semen Causes Poor Sperm Quality and Male Infertility through Induction of Oxidative Stress
Author(s) -
Asghar Beigi Harchegani,
Hamid Reza Rahmani,
Eisa Tahmasbpour,
Alireza Shahriary
Publication year - 2019
Publication title -
current urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.476
H-Index - 13
eISSN - 1661-7657
pISSN - 1661-7649
DOI - 10.1159/000499302
Subject(s) - sperm , semen , hyperviscosity , male infertility , oxidative stress , infertility , medicine , andrology , semen quality , biology , genetics , pregnancy , blood viscosity
Semen hyperviscosity (SHV) is one of the significant factors involved in poor semen quality and male infertility. It also leads major problems during assisted reproduction techniques and in vitro fertilization process. Although influence of SHV on sperm quality, fertilization rate and male infertility have been widely considered, molecular and cellular mechanisms for these abnormalities are not well understood. In this review, we aimed to discuss the proposed cellular and molecular mechanisms of SHV on male reproductive system, the importance of oxidative stress (OS) and the mechanisms by which SHV induces OS and impairment of other antioxidants.