Open AccessThe Effect of Acetylcysteine on Renal Function in Experimental Models of Cyclophosphamide-and Ifosfamide-Induced Cystitis
Author(s) -
Łukasz Dobrek,
Klaudia Nalik-Iwaniak,
Kinga Fic,
Zbigniew Arent
Publication year - 2020
Publication title -
current urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.476
H-Index - 13
eISSN - 1661-7657
pISSN - 1661-7649
DOI - 10.1159/000499245
Subject(s) - acetylcysteine , urology , medicine , blood urea nitrogen , renal function , creatinine , uric acid , urinary system , urine , ifosfamide , cyclophosphamide , kidney , endocrinology , chemotherapy , chemistry , biochemistry , antioxidant , etoposide
Urotoxicity is a characteristic attribute of cy-clophosphamide and ifosfamide. Acetylcysteine is perceived as a uroprotective and possible nephroprotective compound. The purpose of the study was to assess the effect of acetylcysteine treatment on the morphology of the kidneys and the urinary bladder, and renal function in rats with cystitis induced by cyclophosphamide or ifosfamide.