Open AccessDeletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23
Author(s) -
Sima Ulugöl,
Larissa Hering,
Roberto Manzini,
Ana Montalban-Arques,
Claudia Gottier,
Silvia Lang,
Michael Scharl,
Marianne R. Spalinger
Publication year - 2019
Publication title -
inflammatory intestinal diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9403
pISSN - 2296-9365
DOI - 10.1159/000499157
Subject(s) - downregulation and upregulation , azoxymethane , protein tyrosine phosphatase , gene knockdown , microbiology and biotechnology , chemistry , phosphatase , cancer research , endocrinology , biology , phosphorylation , medicine , carcinogenesis , cancer , biochemistry , apoptosis , gene
Knockdown of protein tyrosine phosphatase nonreceptor type 2 ( PTPN2 ) exaggerates IFN-γ-induced intestinal barrier defects, but mice constitutively lacking PTPN2 in epithelial cells (PTPN2xVilCre mice) do not show changes in epithelial function or enhanced susceptibility to experimental colitis. Here, we investigated whether PTPN2 modulates the expression of related tyrosine phosphatases.