Open AccessInfluence of Pre-Existing Mild Cognitive Impairment and Dementia on Post-Stroke Mortality. The Dijon Stroke Registry
Author(s) -
Mathilde Graber,
Lucie Garnier,
Sophie Mohr,
Benoît Delpont,
Christelle Blanc-Labarre,
Catherine Vergely,
Maurice Giroud,
Yannick Béjot
Publication year - 2019
Publication title -
neuroepidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.217
H-Index - 87
eISSN - 1423-0208
pISSN - 0251-5350
DOI - 10.1159/000497614
Subject(s) - medicine , stroke (engine) , dementia , hazard ratio , intracerebral hemorrhage , case fatality rate , population , proportional hazards model , cognitive impairment , pediatrics , epidemiology , confidence interval , disease , subarachnoid hemorrhage , mechanical engineering , environmental health , engineering
Objective: We assessed the association between pre-stroke cognitive status and 90-day case-fatality. Methods: Patients with ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH) were prospectively identified among residents of Dijon, France, between 2013 and 2015, using a population-based registry. Association between pre-stroke cognitive status and case-fatality at 90 days was evaluated using Cox regression. Results: Seven hundred sixty-two patients were identified, and information about pre-stroke cognitive status was obtained for 716 (92.6%) of them, including 603 IS (84.2%) and 113 ICH (15.8%). Before stroke, 99 (13.8%) patients had mild cognitive impairment (MCI) and 98 (13.7%) had dementia. Patients with cognitive impairment were older, had a higher prevalence of several risk factors, more severe stroke, more frequent ICH, and less admission to stroke unit. Case-fatality rate at 90 days was 11.7% in patients without cognitive impairment, 32.3% in MCI patients, and 55.1% in patients with dementia. In multivariable analyses, pre-existing MCI (hazard ratio [HR] 2.22, 95% CI 1.21–4.05, p = 0.009) and dementia (HR 4.35, 95% CI 2.49–7.61, p < 0.001) were both associated with 90-day case-fatality. Conclusion: Pre-stroke MCI and dementia were both associated with increased mortality. These associations were not fully explained by baseline characteristics, pre-stroke dependency, stroke severity or patient management, and underlying reasons need to be investigated.