Impact of Physical Fitness on Cognitive Performance in Patients at a Memory Clinic

Objective: To examine the impact of cardiovascular and motor fitness on cognitive performance in subjects interested in the prevention and early recognition of Alzheimer’s dementia (AD). Methods: The data of 388 participants of a respective project aged between 50 and 85 years were evaluated. Classification of the participants into the groups of “no cognitive impairment” (NCI), “mild cognitive impairment of the amnestic type” (MCIa), and “mild AD” (mAD) was performed by neuropsychological assessment, history of third party, and further clinical, laboratory, or imaging investigations. Subjective memory impairment (SMI) and cognitive blackouts were recorded. Cardiorespiratory fitness (CRF) was assessed by means of the 2-min step test and motor fitness (MF) by means of the 30-s chair-stand test. Results: CRF and MF were reduced in participants with MCIa and mAD. They were negatively correlated with the score for cognitive blackouts. In the group of 50- to 60-year-old nondemented participants those with low CRF and MF performed poorer in various cognitive domains, had a higher score for cognitive blackouts, and more frequently SMI. Conclusion: Low CRF and MF are associated with cognitive impairment. This applies even in 50- to 60-year-old nondemented subjects without marked physical morbidity. These findings support the potential usefulness of physical exercise for dementia prevention.