Open AccessDetection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma
Author(s) -
Shunichi Tsuge,
Behnam Saberi,
Yulan Cheng,
Zhixiong Wang,
Amy Kim,
Harry Luu,
John M. Abraham,
Maria D. Ybanez,
James P. Hamilton,
Florin M. Selaru,
Carlos Villacorta-Martín,
Felix Schlesinger,
Benjamin Philosophe,
Andrew M. Cameron,
Qingfeng Zhu,
Robert A. Anders,
Ahmet Gürakar,
Stephen J. Meltzer
Publication year - 2019
Publication title -
gastrointestinal tumors
Language(s) - English
Resource type - Journals
eISSN - 2296-3766
pISSN - 2296-3774
DOI - 10.1159/000496795
Subject(s) - hepatocellular carcinoma , biology , cancer research , wnt signaling pathway , fusion protein , microbiology and biotechnology , downregulation and upregulation , chromatin remodeling , signal transduction , chromatin , gene , genetics , recombinant dna
Hepatocellular carcinoma (HCC) is now the second-highest cause of cancer death worldwide. Recent studies have discovered a wide range of somatic mutations in HCC. These mutations involve various vital signaling pathways such as: Wnt/ β -Catenin, p53, telome-rase reverse transcriptase (TERT), chromatin remodeling, RAS/MAPK signaling, and oxidative stress. However, fusion transcripts have not been broadly explored in HCC.