Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma | Zendy

Shunichi Tsuge | Zendy; Behnam Saberi | Zendy; Yulan Cheng | Zendy; Zhixiong Wang | Zendy; Amy Kim | Zendy; Harry Luu | Zendy; John Abraham | Zendy; Maria D. Ybanez | Zendy; James P. Hamilton | Zendy; Florin M. Selaru | Zendy; Carlos Villacorta-Martín | Zendy; Felix Schlesinger | Zendy; Benjamin Philosophe | Zendy; Andrew M. Cameron | Zendy; Qingfeng Zhu | Zendy; Robert A. Anders | Zendy; Ahmet Gürakar | Zendy; Stephen J. Meltzer | Zendy

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Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma

Author(s) -

Shunichi Tsuge,

Behnam Saberi,

Yulan Cheng,

Zhixiong Wang,

Amy Kim,

Harry Luu,

John Abraham,

Maria D. Ybanez,

James P. Hamilton,

Florin M. Selaru,

Carlos Villacorta-Martín,

Felix Schlesinger,

Benjamin Philosophe,

Andrew M. Cameron,

Qingfeng Zhu,

Robert A. Anders,

Ahmet Gürakar,

Stephen J. Meltzer

Publication year - 2019

Publication title -

gastrointestinal tumors

Language(s) - English

Resource type - Journals

eISSN - 2296-3766

pISSN - 2296-3774

DOI - 10.1159/000496795

Subject(s) - hepatocellular carcinoma , fusion transcript , fusion , computational biology , biology , fusion gene , cancer research , genetics , gene , linguistics , philosophy

Hepatocellular carcinoma (HCC) is now the second-highest cause of cancer death worldwide. Recent studies have discovered a wide range of somatic mutations in HCC. These mutations involve various vital signaling pathways such as: Wnt/ β -Catenin, p53, telome-rase reverse transcriptase (TERT), chromatin remodeling, RAS/MAPK signaling, and oxidative stress. However, fusion transcripts have not been broadly explored in HCC.

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