The Effects of Probiotics on Symptoms of Depression: Protocol for a Double-Blind Randomized Placebo-Controlled Trial | Zendy

Caroline Wallace | Zendy; Jane A. Foster | Zendy; Cláudio N. Soares | Zendy; Roumen Milev | Zendy

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The Effects of Probiotics on Symptoms of Depression: Protocol for a Double-Blind Randomized Placebo-Controlled Trial

Author(s) -

Caroline Wallace,

Jane A. Foster,

Cláudio N. Soares,

Roumen Milev

Publication year - 2019

Publication title -

neuropsychobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.71

H-Index - 83

eISSN - 1423-0224

pISSN - 0302-282X

DOI - 10.1159/000496406

Subject(s) - randomized controlled trial , medicine , depression (economics) , placebo , clinical trial , bifidobacterium longum , psychiatry , bifidobacterium , alternative medicine , lactobacillus , pathology , genetics , biology , bacteria , economics , macroeconomics

A growing body of evidence has linked mental health outcomes to the gut microbiome. This has led to the investigation of the GI tract as a target for novel treatments and interventions for depression, including probiotic supplementation. Our recent pilot study provided the first evidence of probiotics improving symptoms of depression in treatment-naive depressed patients. To further support and expand upon this evidence, data from the pilot study were used to plan a 16-week, double-blind, randomized, placebo-controlled trial to assess the effects of probiotics on depression. Here, we report the protocol for this trial.

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