Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma | Zendy

Wei Bian | Zendy; Hongfei Zhang | Zendy; Miao Tang | Zendy; Shaojun Zhang | Zendy; Lele Wang | Zendy; Longlong Liu | Zendy; Wenyao Wang | Zendy

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Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma

Author(s) -

Wei Bian,

Hongfei Zhang,

Miao Tang,

Shaojun Zhang,

Lele Wang,

Longlong Liu,

Wenyao Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495825

Subject(s) - microrna , cancer research , hepatocellular carcinoma , in silico , metastasis , biology , epithelial–mesenchymal transition , immunohistochemistry , cancer , pathology , gene , medicine , immunology , biochemistry , genetics

Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, the molecular mechanisms that regulate the expression and function of MTA1 in HCC have not been elucidated.

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