Open AccessPotential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma
Author(s) -
Wei Bian,
Hongfei Zhang,
Miao Tang,
Shaojun Zhang,
Lichao Wang,
Longlong Liu,
Wenyao Wang
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000495825
Subject(s) - microrna , cancer research , hepatocellular carcinoma , in silico , metastasis , biology , epithelial–mesenchymal transition , immunohistochemistry , cancer , pathology , gene , medicine , immunology , biochemistry , genetics
Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, the molecular mechanisms that regulate the expression and function of MTA1 in HCC have not been elucidated.