Open AccessThe Role of Intestinal Fatty Acid Binding Proteins in Protecting Cells from Fatty Acid Induced Impairment of Mitochondrial Dynamics and Apoptosis
Author(s) -
Suparna Sarkar-Banerjee,
Sourav Chowdhury,
Dwipanjan Sanyal,
Tulika Mitra,
Sib Sankar Roy,
Krishnananda Chattopadhyay
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000495672
Subject(s) - microbiology and biotechnology , apoptosis , biology , blot , ectopic expression , mitochondrion , fatty acid , cytochrome c , cell , flow cytometry , biochemistry , gene
The conformation, folding and lipid binding properties of the intestinal fatty acid binding proteins (IFABP) have been extensively investigated. In contrast, the functional aspects of these proteins are not understood and matter of debates. In this study, we aim to address the deleterious effects of FA overload on cellular components, particularly mitochondria; and how IFABP helps in combating this stress by restoring the mitochondrial dynamics.