Open AccessBeta Cell Functional Adaptation and Dysfunction in Insulin Resistance and the Role of Chronic Kidney Disease
Author(s) -
Andraž Stožer,
Radovan Hojs,
Jurij Dolenšek
Publication year - 2019
Publication title -
the nephron journals/nephron journals
Language(s) - English
Resource type - Journals
eISSN - 2235-3186
pISSN - 1660-8151
DOI - 10.1159/000495665
Subject(s) - insulin resistance , intracellular , endocrinology , medicine , beta cell , diabetes mellitus , insulin , insulin oscillation , biology , microbiology and biotechnology , islet
Beta cells are central in the pathophysiology of diabetes, since their functional adaptation maintains euglycemia in insulin-resistant individuals and beta cell dysfunction is required for the clinical picture of frank diabetes. The pathophysiological mechanisms driving compensation and decompensation are incompletely understood and little is known about the influence of chronic kidney disease (CKD) on beta cell function.