Open AccessDysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice
Author(s) -
Yoshiko Gendo,
Takashi Matsumoto,
Naganori Kamiyama,
Benjawan Saechue,
Ciaki Fukuda,
Astri Dewayani,
Shinya Hidano,
Kei Noguchi,
Akira Sonoda,
Takashi Ozaki,
Nozomi Sachi,
Haruna Hirose,
Sotaro Ozaka,
Yuki Eshita,
Kazuhiro Mizukami,
Tadayoshi Okimoto,
Masaaki Kodama,
Tomoko Yoshimatsu,
Haruto Nishida,
Tsutomu Daa,
Yoshio Yamaoka,
Kazunari Murakami,
Takashi Kobayashi
Publication year - 2018
Publication title -
inflammatory intestinal diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9403
pISSN - 2296-9365
DOI - 10.1159/000495462
Subject(s) - suppressor of cytokine signaling 1 , cytokine , immunology , dysbiosis , gut flora , proinflammatory cytokine , inflammatory bowel disease , biology , medicine , inflammation , genetics , gene , disease , suppressor
Both environmental and genetic factors have been implicated in the induction of autoimmune disease. Therefore, it is important to understand the pathophysiological significance of the gut microbiota and host genetic background that contribute to an autoimmune disease such as inflammatory bowel disease (IBD). We have previously reported that mice deficient for suppressor of cytokine signaling-1 (SOCS1), in which SOCS1 expression was restored in T and B cells on an SOCS1 -/- background (SOCS1 -/- Tg mice), developed systemic autoimmune diseases accompanied by spontaneous colitis.